Role of Mitochondrial Iron Uptake in Acetaminophen Hepatotoxicity Early life acetaminophen exposure, glutathione S transferase genes, and development of adolescent asthma in a high risk birth cohort Journal of Allergy and Clinical Immunology g glutamyl cycle. Depletion of glutathione by acetaminophen leads to Download Scientific Diagram Figure 1: CMAJ Tylenol and glutathione, actually explainedhere's the bullet points: * Lots of concern raised on social media re: glutathione depletion and acetaminophen use * Glutathione is used in the metabolism of acetaminophen and Let's take a moment to review acetaminophen (paracetamol), which you likely know as Tylenol. The exact mechanism of action is unclear, but theories suggest it inhibits cyclooxygenase (COX) in the central nervous